TRAINING RHESUS MACAQUES TO TAKE DAILY ORAL ANTIRETROVIRAL THERAPY FOR PRECLINICAL EVALUATION OF HIV PREVENTION AND TREATMENT STRATEGIES.

Training rhesus macaques to take daily oral antiretroviral therapy for preclinical evaluation of HIV prevention and treatment strategies.

BackgroundMacaque models of simian or simian/human immunodeficiency virus (SIV or SHIV) infection are critical for the evaluation of antiretroviral (ARV)-based HIV treatment and prevention strategies.However, modelling human oral ARV administration is logistically challenging and fraught by limited adherence.Here, we Vent Visor developed a protocol

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SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair

Abstract Endometrial cancer (EC) stands as one of the most prevalent malignancies affecting the female genital tract, witnessing a rapid surge in incidence globally.Despite the well-established association of histone methyltransferase SMYD3 with the development and progression of various cancers, its specific oncogenic role in endometrial cancer re

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